Main components of lapacho
The chemical composition of lapacho and its biological action has been studied by scientists for more than 20 years. Among its main components are naphthoquinones, furanonaphthoquinones and anthraquinones. As well as benzoic acid, benzaldehyde derivatives, flavonoids and other compounds.
However, naphthoquinones represent the chemically active group with the highest presence in the plant. For this reason, the biological and therapeutic properties of lapacho have been attributed to these compounds. Lapachol and α and β-lapachone are the three naphthoquinones present in the bark of the lapacho that have received the greatest interest so far.
Among the various therapeutic effects, lapachol has been shown to have potent anticancer properties against various tumor cells , as it affects their proliferation. Similarly, β-lapachone exhibits cytotoxic activity in vitro against various human cell lines. In addition, both compounds have anti-inflammatory and antimicrobial properties.
Pharmacological properties of lapacho
As previously mentioned, lapacho has a considerable number of bio and pharmacological effects.Some of the properties attributed to it are: antifungal, analgesic and antiparasitic action As well as an anti-inflammatory and antitumor effect.
A natural antibiotic
Infections, especially those involving the skin and mucosa, are a serious health problem. These types of infections tend to develop with greater prevalence in patients with a compromised immune system. For example, patients with acquired immunodeficiency syndrome or even patients with chemotherapy or radiotherapy are prone to developing superficial mycoses such as candidiasis, cryptococcosis and aspergillosis.
Lapacho is a medicinal plant that can contribute to the treatment of infections caused by microorganisms. That is why, within its many traditional uses, its intake or topical use is recommended for the treatment of different conditions.
Through its phytocomponents, lapacho inhibits the growth of harmful intestinal bacteria in humans ( study ). Likewise, they have an inhibitory action in vitro against strains of Helicobacter pylori ( study ) and strains of Staphylococcus aureus methicillin resistant ( study , study ) and penicillin ( study ).
Additionally, lapacho also has antimicrobial action against some species of Candida ( study ) and other strains of fungi ( study ). Furthermore, in vitro and animal studies have shown a potential antimalarial activity of lapacho, as well as a beneficial effect against the protozoan parasites that cause trypanosomiasis ( study ).
Finally, lapachol and β-lapachona present in the bark of the lapacho have been shown to have an antiviral action. Β-lapachone has an inhibitory effect ( in vitro ) of reverse transcriptase against some retroviruses, and lapachol interferes in the enzymatic mechanisms necessary for the replication of viruses such as Herpes simplex (type I and II), polio and others.
Lapacho and its anticancer action